A novel palladium-catalyzed amination of aryl halides with amines using rac-P-Phos as the ligand was written by Chen, Huansheng;Wang, Quanrui;Tao, Fenggang. And the article was included in Chinese Journal of Chemistry in 2009.Related Products of 10282-32-3 This article mentions the following:
An efficient palladium-catalyzed amination of aryl halides with amines, using rac-P-Phos as the ancillary ligand and Pd(OAc)2 as the palladium source is developed. The ligand and all of the synthetic intermediates are stable to air and moisture, allowing easy handling. Aromatic amines, e.g. R1C6H4NR2R3 (R1 = H, 4-MeO, 4-Ph, etc.; R2 = H, Me; R3 = PhCH2, 4-MeC6H4, Ph; R2R3 = N-morpholinyl, N-indolyl), were obtained in high yields. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Related Products of 10282-32-3).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Related Products of 10282-32-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts