Clickable Transformation of Nitriles (RCN) to Oxazolyl Sulfonyl Fluoride Warheads was written by Fang, Wan-Yin;Wang, Shi-Meng;Zhang, Zai-Wei;Qin, Hua-Li. And the article was included in Organic Letters in 2020.COA of Formula: C8H4F3NO This article mentions the following:
The protocol for simple, efficient, and mild synthesis of oxazolyl sulfonyl fluorides was developed through Rh2(OAc)4-catalyzed annulation of methyl-2-diazo-2-(fluorosulfonyl)acetate (MDF) or its Et ester derivative with nitriles. This practical method provides a general and direct route to a unique class of highly functionalized oxazolyl-decorated sulfonyl fluoride warheads with great potential in medicinal chem., chem. biol., and drug discovery. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4COA of Formula: C8H4F3NO).
2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.COA of Formula: C8H4F3NO
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts