1,3-Diaryltriazenes: a new class of anorectic agents was written by Hill, David T.;Stanley, Kerry G.;Williams, Janice E. Karoglan;Loev, Bernard;Fowler, Phillip J.;McCafferty, James P.;Macko, Edward;Berkoff, Charles E.;Ladd, Christine B.. And the article was included in Journal of Medicinal Chemistry in 1983.Recommanded Product: 2-Amino-4-(trifluoromethyl)benzonitrile This article mentions the following:
The title compounds I (R = H, Ac, ClCH2CO, EtCO, etc.; R1 = H, Br, Cl, CN, CF3, MeO, CO2Me; R2 = H, Cl, CF3; R3 = H, Br, Cl, CN, CF3, MeO, CO2H, CO2Me; R4 = H, Cl, CF3, CO2H) prepared in part from the aniline precursors II (R = Br, Cl, CN, MeO, CF3, CO2H, CO2Me; R1 = Cl or CF3) were evaluated as anorectic and antiobesity agents in dog, rat, and squirrel monkey. 1,3-bis[2-cyano-5-(trifluoromethyl)phenyl]triazene [58458-08-5] Was the most effective compound Structure activity relations are discussed. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Recommanded Product: 2-Amino-4-(trifluoromethyl)benzonitrile).
2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Recommanded Product: 2-Amino-4-(trifluoromethyl)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts