Synthesis with nitriles. 92. Synthesis of 5-formylcytosine derivatives was written by Jachak, Madhukar;Mittelbach, Martin;Junek, Hans. And the article was included in Heterocycles in 1993.Recommanded Product: 2-Aminopyrimidine-5-carbonitrile This article mentions the following:
The reactivity of 3-dimethylamino-2-formylpropenenitrile (I) with various amino compounds is studied. Thus, condensation of I with anilines gives the corresponding azomethines. Reaction of I with thiourea and guanidine, resp., leads to 5-formylthiocytosine (II) and 2-amino-5-cyanopyrimidine. Also, 2-formyl-3-ureidopropenenitriles can be obtained by reaction of I with urea and substituted ureas. The 2-formyl-3-ureidopropenenitriles can easily be cyclized to 3-substituted 5-formylcytosines. In the experiment, the researchers used many compounds, for example, 2-Aminopyrimidine-5-carbonitrile (cas: 1753-48-6Recommanded Product: 2-Aminopyrimidine-5-carbonitrile).
2-Aminopyrimidine-5-carbonitrile (cas: 1753-48-6) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Recommanded Product: 2-Aminopyrimidine-5-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts