First Synthesis of Phosphorylated Thienopyridines from 2-amino-3-cyanothiophenes and β-ketophosphonates was written by Khalladi, Khaoula;Touil, Soufiane. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2013.Category: nitriles-buliding-blocks This article mentions the following:
In a simple procedure, treatment of 2-amino-3-cyanothiophenes with β-ketophosphonates, under acid catalysis, leads to new 4-amino-5-phosphonothieno[2,3-b]pyridines in good to excellent yields. The structure of obtained products was confirmed by NMR (1H, 31P, 13C) and IR spectroscopies, and by mass spectrometry. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Category: nitriles-buliding-blocks).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts