Ultrasound-promoted synthesis of 2-aminothiophenes accelerated by DABCO utilizing PEG-200 as solvent was written by Liang, Chengyuan;Tang, Zhishu;Qian, Weidong;Shi, Chunyang;Song, Huihui. And the article was included in Journal of Chemical and Pharmaceutical Research in 2014.Recommanded Product: 70291-62-2 This article mentions the following:
An expeditious and greener one-pot procedure was developed for the synthesis of multisubstituted 2-aminothiophene derivatives I (R1 = H; R1R2 = (CH2)3, (CH2)4; R2 = Et, i-Pr, n-Pr, Ph; R3 = CN, CO2Et). In the presence of catalytic amount of DABCO, ketones or aldehydes, dicyanomethane and elemental sulfur were converted into the corresponding 2-aminothiophene derivatives in moderate to high yields in PEG-200 under sonication. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Recommanded Product: 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts