Synthesis and evaluation of the antifungal activity of 2-(substituted-amino)-4,5-dialkyl-thiophene-3-carbonitrile derivatives was written by Mendonca, Francisco J. B. Jr.;Lima-Neto, Reginaldo G.;de Oliveira, Tiago B.;de Lima, Maria do C. A.;Pitta, Ivan R.;Galdino, Suely L.;da Cruz, Rayssa M. D.;de Araujo, Rodrigo S. A.;Neves, Rejane P.. And the article was included in Latin American Journal of Pharmacy in 2011.Related Products of 70291-62-2 This article mentions the following:
Fifteen 2-[(substituted-benzylidene)amino]-5-methyl-thiophene-3-carbonitrile and 2-[(substituted-benzylidene)amino]-4,5-cycloalkyl-thiophene-3-carbonitrile derivatives were synthesized and screened for their in vitro antifungal activity against 42 clin. isolates of Candida (representing 4 different species) and 2 isolates of Cryptococcus. The antifungal activities of these compounds were compared to fluconazole and amphotericin B as standard agents. All compounds presented fungicidal activity at different doses, but a few compounds showed moderate or poor antifungal activity when compared with the standard drugs. The Cryptococcus strains were more sensitive than those of the genus Candida, and the compound 2-[(4-nitrobenzylidene)amino]-4,5-cyclohexyl-thiophene-3-carbonitrile was the most active, with MFC values varying between 100-800 μg/mL. A preliminary SAR study demonstrated that the presence of a cycloalkyl ring linked to the thiophene moiety is essential for antifungal activity, and that the best antifungal candidates are cyclohexyl compounds In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Related Products of 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Related Products of 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts