Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1 was written by Palmer, Brian D.;Smaill, Jeff B.;Rewcastle, Gordon W.;Dobrusin, Ellen M.;Kraker, Alan;Moore, Charles W.;Steinkampf, Randall W.;Denny, William A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Safety of 2-(2,6-Dibromophenyl)acetonitrile This article mentions the following:
A series of 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones, e.g., I, were synthesized and evaluated for their inhibitory properties against the non-receptor kinase c-Src and the G2/M checkpoint kinase Wee1. Overall, the compounds were 10-100-fold more potent inhibitors of c-Src than Wee1, and variation of substituents on the 6-Ph ring did not markedly alter this preference. Solubilizing substituents off the 2-anilino ring in many cases increased Wee1 activity, thus lowering this preference to about 10-fold. 5-Alkyl substituted analogs were generally Wee1 selective, but at the expense of absolute potency. In the experiment, the researchers used many compounds, for example, 2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9Safety of 2-(2,6-Dibromophenyl)acetonitrile).
2-(2,6-Dibromophenyl)acetonitrile (cas: 67197-53-9) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Safety of 2-(2,6-Dibromophenyl)acetonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts