KG-60-piperazine as a new heterogeneous catalyst for Gewald three-component reaction was written by Rezaei-Seresht, Esmail;Tayebee, Reza;Yasemi, Mohammad. And the article was included in Synthetic Communications in 2013.Category: nitriles-buliding-blocks This article mentions the following:
Piperazine supported on amorphous silica (KG-60-piperazine) as a basic catalyst acts in the Gewald three-component reaction of some aldehydes and ketones with malononitrile as well as Et cyanoacetate. The catalyst shows general utility with a variety of starting carbonyl compounds Moreover, the catalyst can be reused for four addnl. cycles without significant loss of the activity. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Category: nitriles-buliding-blocks).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts