An innovative synthesis of tertiary hydroxyl thieno[2,3-d]pyrimidinone skeleton: natural-like product from the tandem reaction of o-aminothienonitrile and carbonyl compound was written by Yang, Junjuan;Shi, Daxin;Hao, Pengfei;Yang, Deli;Zhang, Qi;Li, Jiarong. And the article was included in Tetrahedron Letters in 2016.Product Details of 70291-62-2 This article mentions the following:
A straightforward base accelerant tandem protocol for the synthesis of the tertiary hydroxyl natural-like thieno[2,3-d]pyrimidinone skeleton was developed from the cyclocondensation of o-aminothienonitrile and carbonyl compound The reaction process included PDF conversion and photo-catalytic oxygenation. This synthetic strategy offered an alternative method for regioselective construction of tertiary hydroxylated thieno[2,3-d]pyrimidinone architectures with kinetic, thermodn. control, and six-member ring effect. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Product Details of 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Product Details of 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts