Copper-catalyzed direct amination of benzylic hydrocarbons and inactive aliphatic alkanes with arylamines was written by Yao, Hua;Xie, Bo;Zhong, Xiaoyang;Jin, Shengzhou;Lin, Sen;Yan, Zhaohua. And the article was included in Organic & Biomolecular Chemistry in 2020.Related Products of 10282-32-3 This article mentions the following:
A new synthetic method toward direct C-N bond formation through saturated C-H amination of benzylic hydrocarbons RCH2R1 (R = H, Me, Et; R1 = Ph, 2-chlorophenyl, 3,5-dimethylphenyl, etc.) and inactive aliphatic alkanes such as cyclohexane with primary aromatic amines R2NH2 (R2 = Ph, 3-bromophenyl, pyridin-2-yl, pyrazin-2-yl, etc.) under an inexpensive catalyst/oxidant (Cu/DTBP) system has been developed. Both aminopyridines and anilines could react smoothly with primary and secondary benzylic C-H substrates or cyclohexane to form the corresponding aromatic secondary amines R2NHCH(R)R1 or C6H11NHR2 in moderate to good yields. This protocol has the advantages of wide functional group tolerance and use of readily available raw materials. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Related Products of 10282-32-3).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Related Products of 10282-32-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts