Facile synthesis of polynuclear heterocycles and acyclic C-nucleosides via α-substituted cinamonitrile (II) was written by Abu-zied, Kh. M.;Hussein, H. A. R.;Abu-Hashem, A. A.. And the article was included in Organic Chemistry: An Indian Journal in 2012.Recommanded Product: 70291-62-2 This article mentions the following:
The synthesis of the target compounds was achieved using 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile as a key starting material. This compound was converted to 4-hydrazinyl-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine and a related thione derivative While a 2-hydrazine derivative was obtained upon methylation of the above-mentioned intermediate and reaction of the Me thioether with hydrazine hydrate (99% yield). S-glycosides are produced when a 2,4-dithione derivative reacted with α-D-glucopyranosyl bromide tetraacetate or α-D-galactopyranosyl bromide tetraacetate. Acyclic C-nucleosides were obtained by a reaction of hydrazine derivatives with aldose sugars, aldohexoses (hexoses) or aldopentoses (pentoses) such as D-glucose, D-galactose and D-xylose. The title compounds included derivatives of 9,10-dihydro-8H-cyclopenta[4,5]thieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidine (I) and cyclopenta[4,5]thieno[2,3-d]-1,2,4-triazolo[4,3-a]pyrimidine (II). In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Recommanded Product: 70291-62-2).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Recommanded Product: 70291-62-2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts