Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach was written by Charoensutthivarakul, Sitthivut;Thomas, Sherine E.;Curran, Amy;Brown, Karen P.;Belardinelli, Juan M.;Whitehouse, Andrew J.;Acebron-Garcia-de-Eulate, Marta;Sangan, Jaspar;Gramani, Subramanian G.;Jackson, Mary;Mendes, Vitor;Floto, R. Andres;Blundell, Tom L.;Coyne, Anthony G.;Abell, Chris. And the article was included in ACS Infectious Diseases in 2022.Recommanded Product: 60025-09-4 This article mentions the following:
In this study, SAICAR synthetase (PurC) from Mab was identified as a promising target for novel antibiotics. An inhouse fragment library screen and a high-throughput X-ray crystallog. screen of diverse fragment libraries were explored to provide crucial starting points for fragment elaboration. A series of compounds developed from fragment growing and merging strategies, guided by crystallog. information and careful hit-to-lead optimization, have achieved potent nanomolar binding affinity against the enzyme. Some compounds also show a promising inhibitory effect against Mab and Mtb. This work utilizes a fragment-based design and demonstrates for the first time the potential to develop inhibitors against PurC from Mab. In the experiment, the researchers used many compounds, for example, 4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4Recommanded Product: 60025-09-4).
4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Recommanded Product: 60025-09-4
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts