Uses of 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile in the synthesis of heterocyclic compounds with anticonvulsant, behavioral and CNS antidepressant activities was written by El-Sharkawy, K. A.;El-Sayed, N. N. E.;Zaki, M. Y.. And the article was included in International Research Journal of Pure and Applied Chemistry in 2012.COA of Formula: C8H8N2S This article mentions the following:
A reaction of the cyclopenta[b]thiophene with Ph isothiocyanate gave a thiourea derivative The synthesis of the target compounds was achieved using 2-amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile as a starting material. The latter was treated with the active methylene compounds to provide pyrimidine derivatives N-acylation reaction was achieved using acetic anhydride as a reactant. N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)acetamide was used as a reactant for the synthesis of several derivatives thereof. Finally treatment of N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thien-2-yl)acetamide with different activated nitrile derivatives, hydrazine derivatives gave thienopyridine derivatives and thienopyrimidine derivatives The newly synthesized compounds were tested for anticonvulsant, behavioral and CNS antidepressant activities. The title compounds thus formed included a thienopyrimidine hydrazine imine (I). In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2COA of Formula: C8H8N2S).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.COA of Formula: C8H8N2S
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts