Triazoloquinazolines as a novel class of phosphodiesterase 10A (PDE10A) inhibitors was written by Kehler, Jan;Ritzen, Andreas;Langgard, Morten;Petersen, Sebastian Leth;Farah, Mohamed M.;Bundgaard, Christoffer;Christoffersen, Claus Tornby;Nielsen, Jacob;Kilburn, John Paul. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Category: nitriles-buliding-blocks This article mentions the following:
Novel triazoloquinazolines have been found as phosphodiesterase 10A (PDE10A) inhibitors. Structure-activity studies improved the initial micromolar potency which was found in the lead compound by a 100-fold identifying 5-(1H-benzoimidazol-2-ylmethylsulfanyl)-2-methyl-[1,2,4]triazolo[1,5-c]quinazoline, 42 (PDE10A IC50 = 12 nM) as the most potent compound from the series. Two X-ray structures revealed novel binding modes to the catalytic site of the PDE10A enzyme. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Category: nitriles-buliding-blocks).
2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Category: nitriles-buliding-blocks
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts