Cobalt encapsulated in N-doped graphene sheet for one-pot reductive amination to synthesize secondary amines was written by Liu, Lin;Li, Wenxiu;Qi, Ran;Zhu, Qingqing;Li, Jing;Fang, Yuzhen;Kong, Xiangjin. And the article was included in Molecular Catalysis in 2021.Product Details of 10282-32-3 This article mentions the following:
In this study, an efficient N-doped graphene sheet-coated cobalt catalyst (Co@CN-800) was developed through a simple pyrolysis process, which could gave 99.5% yield of N-benzylaniline by one-pot reductive amination of nitrobenzene with benzaldehyde during at least 5 cycles. Catalyst characterization and control experiments confirmed that the robust catalytic performance of the catalyst is probably due to the synergy effect of in situ generated Co-Nx encapsulated in N-doped graphene layer and appropriate meso-pore structure. Addnl., the substrate adaptability of the catalyst was proved since a variety of corresponding secondary amines RCH2NHR1 (R = C6H5, 4-pyridyl, cyclohexyl, etc.; R1 = C6H5, 4-FC6H4, cyclohexyl, etc.) were smoothly obtained under relatively mild conditions, which makes the secondary amine synthesis strategy based on Co@CN-800 shows excellent application prospect. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Product Details of 10282-32-3).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Product Details of 10282-32-3
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts