Synthesis of antipodagra febuxostat was written by Liu, Xiao-zu;Liu, Pei-jun;Yuan, Ze-li;Hu, Qing-hong. And the article was included in Jingxi Huagong in 2014.Recommanded Product: 5203-15-6 This article mentions the following:
Febuxostat was synthesized from 4-hydroxybenzonitrile via alkylation, bromination, thioformylation, cyclization, cyanation, and hydrolysis. In the improved process, a LiCl-promoted thioformylation needed less time as well as avoided the use of strong acidic conditions. With the catalysis of trace Pd (OAc)2, a cyano group was smoothly installed in the presence of K4 [Fe (CN)6] without anhydrous anaerobic operation. Non-toxic K4 [Fe (CN)6] was used advantageously compared to toxic cyanide sources. The total yield was as high as 64.3%. The structure was confirmed by m.p., 1H-NMR, 13C-NMR and ESI-MS. In the experiment, the researchers used many compounds, for example, 4-iso-Butoxybenzonitrile (cas: 5203-15-6Recommanded Product: 5203-15-6).
4-iso-Butoxybenzonitrile (cas: 5203-15-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Recommanded Product: 5203-15-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts