Expedient one-pot synthesis of indolo[3,2-c]isoquinolines via a base-promoted N-alkylation/tandem cyclization was written by Nguyen, Huy H.;Fettinger, James C.;Haddadin, Makhluf J.;Kurth, Mark J.. And the article was included in Tetrahedron Letters in 2015.Computed Properties of C8H5F3N2 This article mentions the following:
A transition metal-free one-pot protocol for the synthesis of 11H-indolo[3,2-c]isoquinolin-5-amines I [R1 = 9-Me, 9-Cl, 8,9-(MeO)2, etc.; R2 = H, 2-F, 2-MeO] via the atom economical annulation of Et (2-cyano-phenyl)carbamates and 2-cyanobenzyl bromides was developed. This mild and efficient method proceeds via sequential N-alkylation and base-promoted cyclization. Furthermore, optimization data, substrate scope, mechanistic insights and photoluminescence properties were also discussed. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Computed Properties of C8H5F3N2).
2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.Computed Properties of C8H5F3N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts