Nitration of 2-cyanothiophene was written by Reynaud, Pierre;Delaby, Raymond. And the article was included in Bulletin de la Societe Chimique de France in 1955.Recommanded Product: 42137-24-6 This article mentions the following:
Fuming HNO3 (d. 1.49) added dropwise to 2-cyanothiophene in cold Ac2O (10-12°) gives 80% 4-nitro-2-cyanothiophene (I), m. 102° after recrystallization; 5-nitro-2-cyanothiophene (II), m. 45°, also forms in 20% yield. The reaction is kept easily under control by keeping the temperature below 20° with an ice-salt bath, and the isolation of the isomers presents no difficulty. I refluxed 2 h. with concentrated HCl forms 4-nitro-2-thiophenecarboxylic acid (III), m. 154°, after recrystallization I dissolves easily in HCl, and III crystallizes on cooling. This method also offers a simple method of preparation of 3-nitrothiophene, which is obtained in 77% yield from III by decarboxylation with Cu and quinoline in a tube in a metal bath; CO2 is evolved at 160°. In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6Recommanded Product: 42137-24-6).
4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: 42137-24-6
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts