Wu, Xiaofeng et al. published their research in Chemistry – A European Journal in 2008 | CAS: 101219-69-6

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: (R)-4-(1-Hydroxyethyl)benzonitrile

RhIII– and IrIII-catalyzed asymmetric transfer hydrogenation of ketones in water was written by Wu, Xiaofeng;Li, Xiaohong;Zanotti-Gerosa, Antonio;Pettman, Allan;Liu, Jianke;Mills, Allan James;Xiao, Jianliang. And the article was included in Chemistry – A European Journal in 2008.Recommanded Product: (R)-4-(1-Hydroxyethyl)benzonitrile This article mentions the following:

Asym. transfer hydrogenation (ATH) of ketones by formate in neat water is shown to be viable with Rh-TsDPEN and Ir-TsDPEN catalysts, derived in situ from [Cp*MCl2]2 (M = Rh, Ir) and TsDPEN. A variety of ketones were reduced, including non-functionalized aryl ketones, heteroaryl ketones, keto esters, and unsaturated ketones. In comparison with Ir-TsDPEN and the related RuII catalyst, the RhIII catalyst is most efficient in water, affording enantioselectivities of up to 99% ee at substrate/catalyst (S/C) ratios of 100-1000 even without working under an inert atm. The aqueous phase reduction is shown to be highly pH-dependent; the optimum pH windows for TOF greater than 50 molmol-1h-1 for Rh- and Ir-TsDPEN are 5.5-10.0 and 6.5-8.5, resp. Outside the pH window, the reduction becomes slow or stagnant depending on the pH. However, the enantioselectivities erode only under acidic conditions. At a higher S/C ratio, the aqueous ATH by Rh-TsDPEN is shown to be product – as well as byproduct – inhibited; the product inhibition appears to stem at least partly from the reaction being reversible. The aqueous phase reduction is simple, efficient and environmentally benign, thus presenting a viable alternative for asym. reduction In the experiment, the researchers used many compounds, for example, (R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6Recommanded Product: (R)-4-(1-Hydroxyethyl)benzonitrile).

(R)-4-(1-Hydroxyethyl)benzonitrile (cas: 101219-69-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: (R)-4-(1-Hydroxyethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts