Dittler-Klingemann, Andreas M. et al. published their research in Inorganic Chemistry in 1996 | CAS: 7528-78-1

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 3,3′,3”-Nitrilotripropanenitrile

Trigonal-Bipyramidal Copper(II) Complexes with Symmetric and Unsymmetric Tripodal Tetramine Ligands was written by Dittler-Klingemann, Andreas M.;Hahn, F. Ekkehardt. And the article was included in Inorganic Chemistry in 1996.Quality Control of 3,3′,3”-Nitrilotripropanenitrile This article mentions the following:

The syntheses of the aliphatic tripodal tetramine ligands N(CH2CH2CH2NH2)3 (1), N[(CH2CH2CH2NH2)2(CH2CH2NH2)] (2), and N[(CH2CH2CH2NH2)(CH2CH2NH2)2] (3) are reported. The tripodal N4– ligands 13 react with Cu(OH)2 in H2O to give blue Cu(II) complexes. Addition of NH4PF6 to such solutions yields [Cu(N4)(NH3)](PF6)2 [4; N4 = 1, 4a; N4 = 2, 4b; N4 = 3, 4c]. The mol. structures of complexes 4ac were determined by x-ray diffraction. All three complexes can be crystallized from H2O. Selected crystallog. details are as follows 4a [4b] {4c}: formula C9H27CuF12N5P2 [C8H25CuF12N5P2] {C7H23CuF12N5P2}, M = 558.82 [544.79] MLL {530.76} amu, monoclinic [monoclinic] {orthorhombic}, space group P21/c [C2/c] {P21212}, a = 8.9519(14) [30.181(6)] {15.075(5)} Å, b = 16.803(3) [8.914(3)] {12.2939(14)} Å, c 13.834(2) [14.253(4)] {10.064(2)} , β = 94.183(12) [93.76(2)] {90.0}°, V = 2075.3(10) [3826(3)] {1865.2(12)} Å3, Z = 4 [8] {4}, R = 5.10 [3.42] {4.32}, Rw = 6.67 [5.12] {5.23} for 2480 [2137] {1533} absorption corrected structure factors Fo2 â‰?3σ(Fo2) and 262 [255] {245} refined parameters. The complex dications in 4ac exhibit a trigonal-bipyramidal geometry with the tertiary N of the tripodal ligand and the NH3 N in the axial positions. Complexes with the unsym. ligands 2 and 3 possess both five and six membered chelate rings. Depending on the ligand, the size of the cavity for the NH3 ligand increases from 4a to 4c. This leads to a shortening of the Cu-NH3 bond length with the shortest bond of this type observed for 4c. In the experiment, the researchers used many compounds, for example, 3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1Quality Control of 3,3′,3”-Nitrilotripropanenitrile).

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 3,3′,3”-Nitrilotripropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dittler-Klingemann, Andreas M. et al. published their research in Inorganic Chemistry in 1996 | CAS: 7528-78-1

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 3,3′,3”-Nitrilotripropanenitrile

Trigonal-Bipyramidal Copper(II) Complexes with Symmetric and Unsymmetric Tripodal Tetramine Ligands was written by Dittler-Klingemann, Andreas M.;Hahn, F. Ekkehardt. And the article was included in Inorganic Chemistry in 1996.Quality Control of 3,3′,3”-Nitrilotripropanenitrile This article mentions the following:

The syntheses of the aliphatic tripodal tetramine ligands N(CH2CH2CH2NH2)3 (1), N[(CH2CH2CH2NH2)2(CH2CH2NH2)] (2), and N[(CH2CH2CH2NH2)(CH2CH2NH2)2] (3) are reported. The tripodal N4– ligands 13 react with Cu(OH)2 in H2O to give blue Cu(II) complexes. Addition of NH4PF6 to such solutions yields [Cu(N4)(NH3)](PF6)2 [4; N4 = 1, 4a; N4 = 2, 4b; N4 = 3, 4c]. The mol. structures of complexes 4ac were determined by x-ray diffraction. All three complexes can be crystallized from H2O. Selected crystallog. details are as follows 4a [4b] {4c}: formula C9H27CuF12N5P2 [C8H25CuF12N5P2] {C7H23CuF12N5P2}, M = 558.82 [544.79] MLL {530.76} amu, monoclinic [monoclinic] {orthorhombic}, space group P21/c [C2/c] {P21212}, a = 8.9519(14) [30.181(6)] {15.075(5)} Å, b = 16.803(3) [8.914(3)] {12.2939(14)} Å, c 13.834(2) [14.253(4)] {10.064(2)} , β = 94.183(12) [93.76(2)] {90.0}°, V = 2075.3(10) [3826(3)] {1865.2(12)} Å3, Z = 4 [8] {4}, R = 5.10 [3.42] {4.32}, Rw = 6.67 [5.12] {5.23} for 2480 [2137] {1533} absorption corrected structure factors Fo2 ≥ 3σ(Fo2) and 262 [255] {245} refined parameters. The complex dications in 4ac exhibit a trigonal-bipyramidal geometry with the tertiary N of the tripodal ligand and the NH3 N in the axial positions. Complexes with the unsym. ligands 2 and 3 possess both five and six membered chelate rings. Depending on the ligand, the size of the cavity for the NH3 ligand increases from 4a to 4c. This leads to a shortening of the Cu-NH3 bond length with the shortest bond of this type observed for 4c. In the experiment, the researchers used many compounds, for example, 3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1Quality Control of 3,3′,3”-Nitrilotripropanenitrile).

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Quality Control of 3,3′,3”-Nitrilotripropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wiedeman, O. F. et al. published their research in Journal of the American Chemical Society in 1945 | CAS: 7528-78-1

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: 3,3′,3”-Nitrilotripropanenitrile

Some amine derivatives of acrylonitrile was written by Wiedeman, O. F.;Montgomery, W. H.. And the article was included in Journal of the American Chemical Society in 1945.Recommanded Product: 3,3′,3”-Nitrilotripropanenitrile This article mentions the following:

CH2:CHCN (I) (12, 000 cc.), added dropwise to 6500 cc. 28% NH4OH at 30°, gives 1.7% (of the I used) of NCCH2CH2NH2 (II), 88.5% of NH(CH2CH2CN)2 (III), and 6% of N(CH2CH2CN)3 (IV), m. 99°; 880 cc. of I, and 500 cc. NH4OH give 5.8% of II, 83.5% of III, and 1% of IV; 6000 cc. of I and 36, 000 cc. NH4OH give 23.9% of II, 58.9% of III, and 3.3% of IV. Many samples of IV, which remained unchanged at room temperature for several months, decomposed within 24 h. for no apparent reason; no effective stabilizer was found and CO2 apparently accelerated decomposition III is quite stable but some decomposition occurs on distillation at 140-60°/2-5 mm. IV is recovered from the residue of the vacuum distillation of II and III by extraction with hot H2O. Catalytic reduction of II in lots of 5-10 mol in the presence of 1.1 mol of anhydrous NH3 and 2-3 g. Raney Ni (per mole of amine) at pressures of 50-250 atm. for 5-10 h. at 90-125° gives 54% of NH2(CH2)3NH2 (V), 12% of (H2NCH2CH2CH2)2NH (VI), b2-3 100°, d20 0.9307, d25 0.9268, nD25 1.4910, and 3% of (H2NCH2CH2CH2)3N (VII), b2-3 140-50°, d20 0.9591, d25 0.9552, nD25 1.4910. III gives 14% of V, 58% of VI, and 13% of VII. A mixture of 30% II, 65% III, and 4% IV gives 28% of V, 42% of VI, and 13% of VII. I and (CH2)2O give (NCCH2CH2)2O, b2-3 140°, d20 1.0497, d25 1.0457, nD25 1.4404; reduction in the presence of NH3 at 110-15° and 100 atm. for 2 h. yielded 25-30% of low-boiling impurities (some PrNH2), 35-40% of H2N(CH2)3OH, b2-3 60°, d20 0.9832, d25 0.9794, nD25 1.4597, and 20% of (H2NCH2CH2CH2)2O, b3 130-40°, d20 0.9723, d25 0.9685, nD25 1.4780; the residue was 15%. In the experiment, the researchers used many compounds, for example, 3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1Recommanded Product: 3,3′,3”-Nitrilotripropanenitrile).

3,3′,3”-Nitrilotripropanenitrile (cas: 7528-78-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Recommanded Product: 3,3′,3”-Nitrilotripropanenitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dix, Stefan et al. published their research in Chemistry – A European Journal in 2021 | CAS: 63968-85-4

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Computed Properties of C8H4F3NO

Radical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide was written by Dix, Stefan;Golz, Paul;Schmid, Jonas R.;Riedel, Sebastian;Hopkinson, Matthew N.. And the article was included in Chemistry – A European Journal in 2021.Computed Properties of C8H4F3NO This article mentions the following:

Herein, bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent, which easily accessible from inexpensive bulk chems. was introduced. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which was previously prepared via multi-step approaches. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4Computed Properties of C8H4F3NO).

2-(Trifluoromethoxy)benzonitrile (cas: 63968-85-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Computed Properties of C8H4F3NO

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Chunyan et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 10282-32-3

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Electric Literature of C14H12N2

Base-mediated cascade amidination/N-alkylation of amines by alcohols was written by Zhang, Chunyan;Liang, Zuyu;Lu, Fenghong;Jia, Xiaofei;Zhang, Guoying;Hu, Mao-Lin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Electric Literature of C14H12N2 This article mentions the following:

A base-mediated cascade amidination/N-alkylation reaction of amines by alcs. was developed. For the first time, nitriles was identified as an efficient and benign water acceptor reagent in N-alkylation. Notably, the procedure tolerates a series of functional groups, such as methoxyl, halo, vinyl and hetero groups, providing a convenient method to construct different substituted diamino compounds, 15N labeled amine and was scaled up to 1 mol scale offering 138.7 g of the desired product in good yield in one-pot. Mechanistic studies provided strong evidence for the amidination of amines with nitriles facilitated by t-BuOK. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Electric Literature of C14H12N2).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Electric Literature of C14H12N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Qiang et al. published their research in Zhongguo Yiyao Gongye Zazhi in 2007 | CAS: 58168-20-0

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Related Products of 58168-20-0

Synthesis of 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid strontium salt (strontium ranelate) was written by Wang, Qiang;Pan, Hongjuan;Yuan, Zhedong. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2007.Related Products of 58168-20-0 This article mentions the following:

A method for the synthesis of the title compound [i.e., distrontium ranelate, 5-[bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid strontium salt] is reported here. Strontium ranelate (a bone formation stimulant) was synthesized from di-Et 1,3-acetonedicarboxylate [i.e., 3-oxopentanedioic acid 1,5-di-Et ester ] by a cyclization with sulfur and malononitrile, condensation with Et chloroacetate to give 5-[N,N-bis(ethoxycarbonylmethyl)amino]-4-cyano-3-ethoxycarbonylmethyl-2-thiophenecarboxylic acid Et ester, which was subjected to alk. hydrolysis with strontium hydroxide. The overall yield was 34%. In the experiment, the researchers used many compounds, for example, Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0Related Products of 58168-20-0).

Ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate (cas: 58168-20-0) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Related Products of 58168-20-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Trimpin, Sarah et al. published their research in Journal of the American Society for Mass Spectrometry in 2018 | CAS: 64113-86-6

5-Methyl-2-nitrobenzonitrile (cas: 64113-86-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Recommanded Product: 5-Methyl-2-nitrobenzonitrile

Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry was written by Trimpin, Sarah;Lu, I-Chung;Rauschenbach, Stephan;Hoang, Khoa;Wang, Beixi;Chubatyi, Nicholas D.;Zhang, Wen-Jing;Inutan, Ellen D.;Pophristic, Milan;Sidorenko, Alexander;McEwen, Charles N.. And the article was included in Journal of the American Society for Mass Spectrometry in 2018.Recommanded Product: 5-Methyl-2-nitrobenzonitrile This article mentions the following:

Ionization processes have been discovered by which small and large as well as volatile and nonvolatile compounds are converted to gas-phase ions when associated with a matrix and exposed to sub-atm. pressure. Here, we discuss experiments further defining these simple and unexpected processes. Charge separation is found to be a common process for small mol. chems., solids and liquids, passed through an inlet tube from a higher to a lower pressure region, with and without heat applied. This charge separation process produces pos.- and neg.-charged particles with widely different efficiencies depending on the compound and its phys. state. Circumstantial evidence is presented suggesting that in the new ionization process, charged particles carry analyte into the gas phase, and desolvation of these particles produce the bare ions similar to electrospray ionization, except that solid particles appear likely to be involved. This mechanistic proposition is in agreement with previous theor. work related to ion emission from ice. [Figure not available: see fulltext.]. In the experiment, the researchers used many compounds, for example, 5-Methyl-2-nitrobenzonitrile (cas: 64113-86-6Recommanded Product: 5-Methyl-2-nitrobenzonitrile).

5-Methyl-2-nitrobenzonitrile (cas: 64113-86-6) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Recommanded Product: 5-Methyl-2-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Venugopala, Katharigatta N. et al. published their research in Asian Journal of Chemistry in 2018 | CAS: 60979-25-1

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Reference of 60979-25-1

Synthesis and structural elucidation of novel 2,4-disubstituted 1,3-oxazole analogues for pharmacological properties was written by Venugopala, Katharigatta N.. And the article was included in Asian Journal of Chemistry in 2018.Reference of 60979-25-1 This article mentions the following:

Novel 2,4-disubstituted 1,3-oxazole analogs (3a-i) were designed and synthesized between 1-[3,5-bis(trifluoromethyl)-phenyl]-2-bromoethan-1-one and substituted amides by microwave assisted method. 2,4-Disubstituted 1,3-oxazole analogs obtained were at excellent yields and purity of the compound was ascertained by HPLC. The chem. structure of these compounds was elucidated by spectrometric (FTIR, NMR and LCMS) and elemental anal. Microwave method influenced the better yield and reduction in reaction time when compared to conventional reflux method. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methoxybenzonitrile (cas: 60979-25-1Reference of 60979-25-1).

3-Amino-4-methoxybenzonitrile (cas: 60979-25-1) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Reference of 60979-25-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Woo, Stone et al. published their research in Nature (London, United Kingdom) in 2022 | CAS: 36057-44-0

4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Name: 4-methoxypicolinonitrile

Synthesis and target annotation of the alkaloid GB18 was written by Woo, Stone;Shenvi, Ryan A.. And the article was included in Nature (London, United Kingdom) in 2022.Name: 4-methoxypicolinonitrile This article mentions the following:

Ingestion of alkaloid metabolites from the bark of Galbulimima (GB) sp. leads to psychotropic and excitatory effects in humans1-4. Limited, variable supply of GB alkaloids5, however, has impeded their biol. exploration and clin. development6. Here we report a solution to the supply of GB18, a structural outlier and putative psychotropic principle of Galbulimima bark. Efficient access to its challenging tetrahedral attached-ring motif required the development of a ligand-controlled endo-selective cross-electrophile coupling and a diastereoselective hydrogenation of a rotationally dynamic pyridine. Reliable, gram-scale access to GB18 enabled its assignment as a potent antagonist of κ- and μ-opioid receptors-the first new targets in 35 years-and lays the foundation to navigate and understand the biol. activity of Galbulimima metabolites. In the experiment, the researchers used many compounds, for example, 4-methoxypicolinonitrile (cas: 36057-44-0Name: 4-methoxypicolinonitrile).

4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Name: 4-methoxypicolinonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Grochowski, E. et al. published their research in Bulletin de l’Academie Polonaise des Sciences, Serie des Sciences Chimiques in 1972 | CAS: 37812-51-4

4-(Morpholinomethyl)benzonitrile (cas: 37812-51-4) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).HPLC of Formula: 37812-51-4

Cyanobenzyl sulfates as alkylating agents. Alkylation of amines with bis(cyanobenzyl)sulfate was written by Grochowski, E.;Boleslawska, T.. And the article was included in Bulletin de l’Academie Polonaise des Sciences, Serie des Sciences Chimiques in 1972.HPLC of Formula: 37812-51-4 This article mentions the following:

(2-NCC6H4CH2)2SO4 (I) and (4-NCC6H4CH2)2SO4 (II) are powerful alkylating agents for amines. Thus the resp. mono-(cyanobenzyl) derivatives were obtained in 95-8% yield by treating I with morpholine or pyridine or treating II with PhNH2, PhCH2NH2, cyclohexylamine, morpholine, or pyridine. II was prepared in 68% yield from 4-NCC6H4CH2Br and Ag2SO4. Reaction of I with primary amines gave iminoisoindoles, however. In the experiment, the researchers used many compounds, for example, 4-(Morpholinomethyl)benzonitrile (cas: 37812-51-4HPLC of Formula: 37812-51-4).

4-(Morpholinomethyl)benzonitrile (cas: 37812-51-4) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).HPLC of Formula: 37812-51-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts