Month: January 2023

Synthesis of substituted 2-alkylquinolines by visible-light photoredox catalysis was written by Mei, Yousheng;Liu, Jie;Wang, Lei;Li, Pinhua. And the article was included in Organic & Biomolecular Chemistry in 2020.Electric Literature of C8H8N2 This article mentions the following:

The condensation of anilines RNH₂ (R = 2-methyl-4-chlorophenyl, 4-chlorophenyl, 2-methoxyphenyl, etc.) and alkenyl ethers such as ethoxyethene, (E)-1-ethoxyprop-1-ene, (E)-1-ethoxybut-1-ene has been demonstrated by employing visible-light photoredox catalysis. The resulting method enables the synthesis of substituted 2-alkylquinolines I [R¹ = Me, Et, Pr; R² = H, Me, Et; R³ = H, I, Br, etc.; R⁴ = CN, COOMe, Me, etc.; R⁵ = H, Br, Me, etc.], II (R⁶ = H, CF₃, Et, OMe; R⁷ = H, Cl, Br) under mild and simple conditions with good substrate scope and high yields. In the experiment, the researchers used many compounds, for example, 3-Amino-4-methylbenzonitrile (cas: 60710-80-7Electric Literature of C8H8N2).

3-Amino-4-methylbenzonitrile (cas: 60710-80-7) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Electric Literature of C8H8N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pot, Atom, Step Economic (PASE) Approach towards (Aza)-2,2′-Bipyridines: Synthesis and Photophysical Studies was written by Khasanov, Albert F.;Kopchuk, Dmitry S.;Kim, Grigory A.;Slepukhin, Pavel A.;Kovalev, Igor S.;Santra, Sougata;Zyryanov, Grigory V.;Majee, Adinath;Chupakhin, Oleg N.;Charushin, Valery N.. And the article was included in ChemistrySelect in 2018.Product Details of 36057-44-0 This article mentions the following:

An efficient approach towards α-unsubstituted-2,2′-bipyridines, their aza-analogs and 3,6-disubstituted-1,2,4-triazine precursors is reported via pot, atom, step economic (PASE) process starting from isonitrosoacetophenone hydrazone and readily available hetero-arylnitriles. The crystal structures of three key compounds were confirmed by means of X-ray diffraction anal.In addition the photophys. properties of the new (aza)-2,2′-pyridines were studied. In the experiment, the researchers used many compounds, for example, 4-methoxypicolinonitrile (cas: 36057-44-0Product Details of 36057-44-0).

4-methoxypicolinonitrile (cas: 36057-44-0) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Product Details of 36057-44-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Physicochemical Investigation on the Complexes of Co(II), Ni(II) and Cu(II) with Aminocyclodiphosph(V)azane Derivative was written by Abd-Ellah, I. M.;El-Sayed, B. A.;El-Nawawy, M. A.;Alaghaz, A. M. A.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2002.SDS of cas: 70291-62-2 This article mentions the following:

Co(II), Ni(II), and Cu(II) form 2:1 complexes with aminocyclodiphosph(V)azane derivative The complexes have been investigated in solution by the spectrophotometric molar ratio and conductometric methods. The ligand and its complexes have been isolated in solid state and characterized on the basis of microanal., IR, electronic, magnetic moment, ¹H NMR and mass spectral data. The cobalt and nickel complexes were assigned to be in tetrahedral structure while the copper complex is assigned to be in square planar. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2SDS of cas: 70291-62-2).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. SDS of cas: 70291-62-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Intramolecular charge transfer properties of dicyanovinyl-substituted aromatics was written by Katritzky, Alan R.;Zhu, Dong Wei;Schanze, Kirk S.. And the article was included in Journal of Physical Chemistry in 1991.Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile This article mentions the following:

A series of five dicyanovinyl (DCV)-substituted aromatic compounds (referred to collectively as Ar-DCV, where Ar = 1-Ph, 1-naphthyl, 9-anthracenyl, 9-phenanthrenyl, and 1-pyrenyl) were prepared and their ground- and excited-state properties were examined Solvent-dependent NMR studies indicate that the ground state of the Ar-DCV compounds is polar. Strong intramol. charge transfer (ICT) absorption bands were observed for each compound The position of the ICT absorption is nearly independent of solvent polarity and the molar absorptivity is related to the twist angle between the aromatic donor and the DCV acceptor. The fluorescence spectra are highly solvatochromatic and the fluorescence energy correlates with the solvent polarity parameter Δf in a variety of solvents. The fluorescence quantum yields are low and no emission was observed from phenyl-DCV. An excited-state model is proposed which explains the solvent dependence of the ICT absorption and emission of the series of Ar-DCV compounds In the experiment, the researchers used many compounds, for example, 2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile).

2-(Anthracen-9-ylmethylene)malononitrile (cas: 55490-87-4) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 2-(Anthracen-9-ylmethylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis of thienopyrimidine-pyrazolo[3,4-b]pyridine hybrids was written by Park, Jae Woo;Song, Yang-Heon. And the article was included in Heterocyclic Communications in 2017.Electric Literature of C8H8N2S This article mentions the following:

New hybrid compounds, thienopyrimidinyl-1H-pyrazolo[3,4-b]pyridines I [R¹ = R² = H; R¹R² = (CH₂)₃, (CH₂)₄; R³ = 4-Me, 4-MeO, 4-Br] and II were efficiently synthesized by the three-component reaction of 3-phenyl-1-(thienopyrimidin-4-yl)-1H-pyrazol-5-amines, benzoylacetonitrile and an aromatic aldehydes in the presence of FeCl₃ on basic alumina. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Electric Literature of C8H8N2S).

2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Electric Literature of C8H8N2S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856 was written by Perreault, Stephane;Chandrasekhar, Jayaraman;Cui, Zhi-Hua;Evarts, Jerry;Hao, Jia;Kaplan, Joshua A.;Kashishian, Adam;Keegan, Kathleen S.;Kenney, Thomas;Koditek, David;Lad, Latesh;Lepist, Eve-Irene;McGrath, Mary E.;Patel, Leena;Phillips, Bart;Therrien, Joseph;Treiberg, Jennifer;Yahiaoui, Anella;Phillips, Gary. And the article was included in Journal of Medicinal Chemistry in 2017.Category: nitriles-buliding-blocks This article mentions the following:

Phosphoinositide 3-kinase (PI3K) beta signaling is required to sustain cancer cell growth in which the tumor suppressor phosphatase and tensin homolog (PTEN) has been deactivated. This manuscript describes the discovery, optimization, and in vivo evaluation of a novel series of PI3Kbeta/delta inhibitors in which PI3Kbeta potency was built in a PI3Kdelta-selective template. This work led to the discovery of a highly selective PI3Kbeta/delta inhibitor displaying excellent pharmacokinetic profile and efficacy in a human PTEN-deficient LNCaP prostate carcinoma xenograft tumor model. In the experiment, the researchers used many compounds, for example, 4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4Category: nitriles-buliding-blocks).

4-Amino-6-chloropyrimidine-5-carbonitrile (cas: 60025-09-4) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electrochemical reduction of pristinamycin I_A and related streptogramins in aqueous acidic medium was written by Largeron, M.;Vuilhorgne, M.;Le Potier, I.;Auziel, N.;Bacque, E.;Paris, J. M.;Fleury, M. B.. And the article was included in Tetrahedron in 1994.Recommanded Product: 10282-32-3 This article mentions the following:

The electrochem. reduction of the picolinoyl residue of pristinamycin I_A and related streptogramins was performed at a mercury cathode, in aqueous acidic medium. The presence of a peptidic lactone residue at the amide nitrogen atom markedly modified the expected cathodic behavior of pyridyl carboxamides: in particular, the pyridyl ring was reduced to tetrahydropyridine. Thanks to a series of model heterocyclic carboxamides, increasing steric hindrance at the amide nitrogen position was shown to lead to enhanced reduction of the heterocyclic ring. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3Recommanded Product: 10282-32-3).

4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitriles are susceptible to hydrogenation over diverse metal catalysts. The reaction can afford either the primary amine (RCH2NH2) or the tertiary amine ((RCH2)3N), depending on conditions.Recommanded Product: 10282-32-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

A highly specific tetrazole-based chemosensor for fluoride ion: A new sensing functional group based on intramolecular proton transfer was written by Li, Ju-Ying;Zhou, Xin-Qi;Zhou, Yi;Fang, Yuan;Yao, Cheng. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2013.COA of Formula: C14H14N2O2 This article mentions the following:

A simple but highly selective colorimetric and fluorescent chemosensor for fluoride ion was prepared based on coumarin chromophore and 1H-tetrazole. Tetrazole functional group provided a novel sensing functional group containing the ESIPT structure for designing fluoride chemosensor. In the experiment, the researchers used many compounds, for example, 7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6COA of Formula: C14H14N2O2).

7-(Diethylamino)-2-oxo-2H-chromene-3-carbonitrile (cas: 51473-74-6) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.COA of Formula: C14H14N2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pyrrolo[1,2-a][1,4]benzodiazepine: A novel class of non-azole anti-dermatophyte anti-fungal agents was written by Meerpoel, Lieven;Van Gestel, Jef;Van Gerven, Frans;Woestenborghs, Filip;Marichal, Patrick;Sipido, Vic;Terence, Gilkerson;Nash, Roger;Corens, David;Richards, Ray D.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.HPLC of Formula: 53312-77-9 This article mentions the following:

Broad screening revealed compound I to be a novel anti-fungal agent with high specificity towards dermatophytes. The anti-fungal structure-activity relationship of this novel class of 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines is described together with its mode of action that appeared to be the inhibition of squalene epoxidase. Preliminary in vivo results of the most active compounds are also reported. In the experiment, the researchers used many compounds, for example, 2-Amino-3-chlorobenzonitrile (cas: 53312-77-9HPLC of Formula: 53312-77-9).

2-Amino-3-chlorobenzonitrile (cas: 53312-77-9) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.HPLC of Formula: 53312-77-9

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Meisenheimer-type adducts from thiophene derivatives. Part 6. A kinetic and thermodynamic study of substituent effects on the formation of some non-gem adducts was written by Arnone, Caterina;Consiglio, Giovanni;Spinelli, Domenico;Dell’Erba, Carlo;Sancassan, Fernando;Terrier, Francois. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1989.Application of 42137-24-6 This article mentions the following:

The rate and equilibrium constants for the formation of the Meisenheimer-type adducts I and II from 4-nitro-2-X- or 2-nitro-4-X-thiophenes and sodium methoxide have been measured at 25° in methanol or methanol-DMSO mixtures The observed stability and reactivity patterns have been interpreted in the light of the hyper-ortho relation in the thiophene ring and the special ability of the nitro group to stabilize effectively the adducts from a para-like position also. In the experiment, the researchers used many compounds, for example, 4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6Application of 42137-24-6).

4-Nitrothiophene-2-carbonitrile (cas: 42137-24-6) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Application of 42137-24-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts