A recyclable Cu/Al-HT catalyst for amination of aryl chlorides was written by Likhar, Pravin R.;Arundhathi, R.;Kantam, M. Lakshmi. And the article was included in Tetrahedron Letters in 2007.COA of Formula: C14H12N2 This article mentions the following:
A simple Cu/Al-HT catalyzed amination of aryl chlorides with primary and secondary aromatic amines was developed. This ligand-free heterogeneous Cu/Al-HT catalyst, in conjunction with base, also efficiently works for the amination of aryl chlorides with cycloalkyl amines. This method tolerates a variety of functional groups and does not require an expensive additive. In the experiment, the researchers used many compounds, for example, 4-(Benzylamino)benzonitrile (cas: 10282-32-3COA of Formula: C14H12N2).
4-(Benzylamino)benzonitrile (cas: 10282-32-3) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. COA of Formula: C14H12N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts