Liu, Yuan published the artcileSynthesis of 3-Amino-7-(N,N-Dimethylamino)-2-Substituted-5-Phenylphenazin-5-Ium Chlorides by Oxidative Cyclization, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is dimethylamino phenazinium chloride preparation green chem; toluidine aminodimethyamine aniline oxidative cyclization potassium permanganate; Nitroaniline; aniline; derivatives; oxidative cyclizatio; phenzine; potassium permanganate; synthesis.
Herein, the use of potassium permanganate as an oxidant to synthesize 3-amino-7-(N, N-dimethylamino)-2-substituted-5-phenylphenazin-5-ium chlorides I (X = Me, Et, Br, etc.) via sequential aniline arylation is reported. The synthesized products were obtained via reaction of various o-substituted toluidines with 4-amino-N,N-dimethyamine and aniline using potassium permanganate as an oxidant under different conditions such as temperature, pH, reaction time and the ratio of raw materials. IR (IR) absorption data were acquired on a Thermo Nicolet Nexus 670 FT-IR spectrometer with DTGS KBr detector. The total C, H, N, content was measured by the elemental analyzer. The yields of the products ranging from 42.5% to 75.8% was obtained based on the electrophilic ability of different substituted groups under the temperature of 95°, pH 4.5 and the reaction time of 8hrs. This route is a simple, economic, efficient and environmentally friendly.
Current Organic Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts