Ruan, Shixiang published the artcileFacile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters, HPLC of Formula: 100-70-9, the main research area is nitrile preparation; primary amide dehydration lead diacetate catalyst.
The synthesis of nitriles RCN [R = n-Pr, 2-MeC6H4, 2-pyridyl, etc.] under mild conditions was achieved via dehydration of primary amides using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only byproduct, water from the system. Both aliphatic and aromatic nitriles could be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chem. calculations, and the crucial role the anionic ligand played in the transformations were revealed.
Molecular Catalysis published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts