Hu, Fang-Peng published the artcileBase-promoted Lewis acid catalyzed synthesis of quinazoline derivatives, Quality Control of 1885-29-6, the main research area is quinazolinone preparation; amide oxazoline preparation heterocyclization Lewis acid catalyst.
A one-pot protocol has been developed for the synthesis of quinazolinones I (R = Me, Ph, 2-thienyl, etc.; R1 = H, 7-Me, 6-Cl, 6-Br, 7-Br, 5-F) from amide-oxazolines II (R2 = H, 5-Me, 4-Cl, 4-Br, 5-Br, 3-F) with TsCl via a cyclic 1,3-azaoxonium intermediate and 6π electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones I.
Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts