Forni, Jose A. published the artcileAn electrochemical γ-C-H arylation of amines in continuous flow, Formula: C8H4N2, the main research area is arylated sulfonamide regioselective preparation; cyanoarene aryl sulfonamide electrochem gamma CH arylation continuous flow.
A regioselective C(sp3)-C(sp2) cross coupling reaction between inert γ-C(sp3)-H bonds in aliphatic amines and cyanoarenes under electrochem. conditions in flow was reported. The developed methodol. took advantage of a removable redox active auxiliary, which triggered selective 1,7-hydrogen atom transfer to functionalized an aliphatic C-H bond at the γ-position of an alkyl amine. In this reaction, a cyanoarene radical anion functions as both a selective arylating reagent and a redox active mediator, enabled the controlled one electron reduction of the redox active auxiliary. This strategy offered a new approach toward γ-C(sp3)-H bond functionalization allowing generation of, amongst others, sterically crowded carbon centers under mild reaction conditions and in the absence of addnl. catalysts or radical initiators.
Tetrahedron Letters published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts