Muley, Arabinda published the artcileSynthesis, structure, spectral, redox properties and anti-cancer activity of Ruthenium(II) Arene complexes with substituted Triazole Ligands, Computed Properties of 100-70-9, the main research area is cymene ruthenium pyridyltriazolylpyridine preparation crystal mol structure antitumor activity; arene ruthenium pyridyltriazolylpyridine complex preparation crystal mol structure antitumor.
Three versatile half-sandwich ruthenium(II) p-cymene complexes bearing substituted triazole ligands exhibit promising cancer cell growth inhibition activity towards A549 lung adenocarcinoma and MDA-MB-231 breast adenocarcinoma cells. In this context, the triazole based phthalimide protected new ligand (2-(3, 5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione) (L1) was prepared Three ruthenium(II) p-cymene complexes [Ru(η6-p-cymene)(L1)Cl]Cl: [1]Cl, L1: (2-(3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione), [Ru(η6-p-cymene)(L2)Cl]Cl: [2]Cl and [Ru(η6-p-cymene)(L2)Cl](PF6): [2](PF6), L2 (2,2′-(4-(1H-pyrrol-1-yl)-4H-1,2,4-triazole-3,5-diyl)dipyridine) have been successfully synthesized and characterized by different spectral and anal. tools. Pyrrole protected substituted ruthenium complexes [2]Cl and [2](PF6) have been successfully identified structurally by single-crystal x-ray diffraction studies and confirmed the successful anion exchange. The redox properties of the ligands and the targeted metal complexes have been carefully examined Cellular staining, live-cell imaging and MTT assay have been performed for all the complexes. Authors have demonstrated that their synthesized ruthenium(II) p-cymene complexes are capable of inducing significant cytotoxicity in A549 lung cancer cell lines, with an IC50 values of 6.56 ± 0.31μM, 4.74 ± 0.2μM and 13.67 ± 0.64μM and in MDA-MB-231 breast cancer cell lines with an IC50 values of 1.13 ± 0.046μM, 0.36 ± 0.016μM and 11.32 ± 0.49μM for [1]Cl, [2]Cl and [2](PF6) resp.
Journal of Organometallic Chemistry published new progress about Antitumor agents (mammary gland and lung). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts