Sun, Zhuming published the artcileHarnessing the Intrinsic Reactivity of 2-Cyano-Substituted Heteroarenes to Achieve Programmable Double Alkylation, Related Products of nitriles-buliding-blocks, the main research area is alpha tertiary amine regioselective preparation; cyanoarene acid sequential double alkylation photochem cross coupling.
Study of tertiary radicals, generated through visible light decarboxylation, alkylating 2-cyanoarenes through radical cross-coupling at ipso- or para- positions of cyano groups was reported. Synthesis of a variety of α-tertiary amines containing quaternary centers, e.g., I was described. The approach enabled regioselective sequential double alkylation on either 2-cyanopyridine or 2-cyanopyrimidine with high efficiency. This report illustrated synthetic utility of α-heteroatom-substituted tertiary radicals in synthesis of substituted heteroarenes.
Advanced Synthesis & Catalysis published new progress about Alkylation catalysts, regioselective. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts