Geyl, Kirill published the artcileConvenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C-H activation of N-oxides, Recommanded Product: Picolinonitrile, the main research area is oxadiazolyl pyridine oxide dialkylcyanamide methanesulfonic acid catalyst; dialkyl oxadiazolyl pyridinyl urea regioselective preparation green chem.
Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C-H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “”lead-like”” scaffolds for medicinal chem. Atom-economy, environmental friendliness (no halide-containing or toxic reagents), simple work-up, as well as scalability are the main advantages of the employed procedure.
Tetrahedron Letters published new progress about C-H bond activation (regioselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts