Carpentier, Florian published the artcileSynthesis of 5-Substituted 1H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan, Formula: C6H4N2, the main research area is tetrazole preparation; nitrile trimethylazide continuous flow polymer supported organotin catalyst; valsartan preparation angiotensin II receptor.
An efficient continuous flow process for the synthesis of 5-substituted 1H-tetrazoles I [R = n-Bu, Ph, 2-thienyl, etc.] was described. The polymer-supported organotin azide, which was in situ generated with a polystyrene-supported triorganotin alkoxide and trimethylsilylazide and immobilized in a packed bed reactor. The process involved the reaction between a polymer-supported triorganotin azide, trimethylazide and organic nitriles. The process was also applied for the synthesis of valsartan an angiotensin II receptor antagonist II. This approach was simple, fast (it took from 7.5 to 15 min), and guaranted a low concentration of tin residues in the products (<5 ppm). Organic Process Research & Development published new progress about Angiotensin II receptor antagonists. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts