Marchese, Austin D. published the artcileNickel-Catalyzed Enantioselective Carbamoyl Iodination: A Surrogate for Carbamoyl Iodides, COA of Formula: C7H6N2, the main research area is iodooxindole preparation enantioselective; styrene carbamoyl chloride carboiodination nickel catalyst.
This work reports the enantioselective formal transfer of a carbamoyl iodide across 1,1-disubstituted styrenes 2-N(C(O)Cl)R-3-R1-4-R2-5-R3-6-R4-C6C(=CH2)R5 (R = Me, prop-2-en-1-yl, 4-methoxybenzyl; R1 = H, F; R2 = H, F, Cl, OMe, CF3; R3 = H, Cl, OMe, C(O)OCH3; R4 = H, F, OMe; R5 = Me, Ph, cyclopropyl, etc.) using Ni-catalysis. Employing an air-stable Ni(II) precatalyst and a com. available chiral ligand ((S)-tBuPHOX), enantioenriched 3,3-disubstituted iodooxindoles I were obtained in up to 90% yield and up to 97:3 e.r. This methodol. was applied to the total synthesis of (-)-esermethole and (-)-phenserine.
ACS Catalysis published new progress about Carbamoylation (stereoselective). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts