Vergani, Barbara published the artcileNovel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation, HPLC of Formula: 100-70-9, the main research area is benzohydroxamate pentaheterocycle preparation histone deacetylase inhibitor.
Histone deacetylase 6 (HDAC6) is a peculiar HDAC isoform whose expression and functional alterations were correlated with a variety of pathologies such as autoimmune disorders, neurodegenerative diseases, and cancer. It is primarily a cytoplasmic protein, and its deacetylase activity is focused mainly on non-histone substrates such as tubulin, heat shock protein (HSP)90, Foxp3 and cortactin, to name a few. Selective inhibition of HDAC6 does not show cytotoxic effects in healthy cells, normally associated with the inhibition of Class I HDAC isoforms. Here the authors describe the design and synthesis of a new class of potent and selective HDAC6 inhibitors that bear a pentaheterocyclic central core. These compounds show a remarkably low toxicity both in vitro and in vivo and are able to increase the function of regulatory T cells (Tregs) at well tolerated concentrations, suggesting a potential clin. use for the treatment of degenerative, auto-immune diseases and organ transplantation.
Journal of Medicinal Chemistry published new progress about Histone deacetylase inhibitors. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts