Fatahi, Hosna published the artcileSynthesis of α-Aminonitriles and 5-Substituted 1H-Tetrazoles Using an Efficient Nanocatalyst of Fe3O4@SiO2-APTES-supported Trifluoroacetic Acid, Synthetic Route of 100-70-9, the main research area is iron oxide supported silylpropylammonium trifluoroacetic acid preparation surface structure; carbonyl compound aniline heterogeneous catalyst Strecker reaction green chem; phenylamino acetonitrile preparation; sodium azide aryl nitrile heterogeneous catalyst cycloaddition green chem; aryl tetrazole preparation.
Fe3O4@SiO2-APTES-supported trifluoroacetic acid nanocatalyst was used for the one-pot synthesis of α-aminonitriles via a three-component reaction of aldehydes (or ketones), amines and sodium cyanide. This method produced a high yield of 75-96% using only a small amount of the catalyst (0.05 g) in EtOH at room temperature The catalyst was also employed for the synthesis of 5-substituted 1H-tetrazoles from nitriles and sodium azide in EtOH at 80°. The tetrazoles were produced with good-to-excellent yields in a short reaction time of 4 h. Both synthetic methods were carried out in the absence of an organic volatile solvent. Because the supported trifluoroacetic acid generated a solid acid on the surface, thus the acid corrosiveness was not a serious challenge. This heterogeneous nanocatalyst was magnetically recovered and reused several times without significant loss of catalytic activity.
Journal of Heterocyclic Chemistry published new progress about [3+2] Cycloaddition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts