He, Dandan published the artcileSynthesis of Densely Substituted Pyridine Derivatives from 1-Methyl-1,3-(ar)enynes and Nitriles by a Formal [4+2] Cycloaddition Reaction, Synthetic Route of 100-70-9, the main research area is pyridine preparation regioselective chemoselective; isoquinoline preparation regioselective chemoselective; benzothienopyridine preparation regioselective chemoselective; aryl alkyne nitrile cycloaddition.
An attractive method for assembling densely substituted pyridine derivatives I [R = Ph, 4-MeC6H4, 2-naphthyl, etc.; R1 = H, 6-Me, 6-Ph, 7-Ph, 8-F; R2 = H, Me, CN, Ph; R3 = Ph, 4-FC6H4, 2-pyridyl, etc.], II [R4 = Ph, 4-MeOC6H4, 3-ClC6H4, etc.; R5 = Ph, 2-naphthyl, 2-pyridyl, etc.; Y = O, S], III [R6 = H, 3-Me, 4-MeO, etc.] from 1-methyl-1,3-(ar)enynes and nitriles via a formal [4+2] cycloaddition had been established. The well-balanced affinities of two alkali metal salts enabled C(sp3)-H bond activation and excellent chemo- and regioselectivities. Exptl. studies revealed that nitrile functioned only as a partial nitrogen source for pyridine synthesis, and the addition of a metalated imine intermediate to an intramol. alkyne was the rate-limiting step.
Organic Letters published new progress about [4+2] Cycloaddition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts