Kato, Yoshimi published the artcileDevelopment of Pseudo-C2-symmetric Chiral Binaphthyl Monocarboxylic Acids for Enantioselective C(sp3)-H Functionalization Reactions under Rh(III) Catalysis, Application of Picolinonitrile, the main research area is dioxazolone alkylpyridine carboxylic acid rhodium catalyst enantioselective amidation; pyridinylpropyl carboxamide preparation.
Herein, pseudo-C2-sym. tunable chiral carboxylic acids with a binaphthyl backbone and their application to enantioselective C(sp3)-H amidation reactions of 2-alkylpyridines and related heteroaromatic substrates were reported. The fixed cyclic structure and pseudo-C2-symmetry of the developed chiral carboxylic acids reduced the conformational flexibility and ambiguity. The combination of an optimal chiral carboxylic acid and a sterically hindered rhodium catalyst (Cp*tBuRhIII) exhibited high enantioselectivity (up to 96:4 er).
ACS Catalysis published new progress about Amidation (stereoselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application of Picolinonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts