Cheng, Wenchen published the artcileTBN-Catalyzed Dehydrative N-Alkylation of Anilines with 4-Hydroxybutan-2-one, Formula: C7H6N2, the main research area is aminoketone green preparation; aniline hydroxybutanone dehydrative alkylation tert butyl nitrite catalyst.
An efficient protocol was developed for the dehydrative N-alkylation of anilines with 4-hydroxybutan-2-one using TBN as catalyst in presence of TEMPO, which was different than TEMPO/TBN catalyzed oxidation reactions. A range of anilines reacted successfully with 4-hydroxybutan-2-one to generate the β-aminoketones RNHCH2CH2C(O)CH3 [R = Ph, 4-FC6H4, 3,4-di-ClC6H3, etc.] in good yields. Mechanistic studies revealed that this reaction most possibly proceeded through aza-Michael addition Water was the only byproduct, making it more environmentally friendly. The gram-scale reactions verified synthetic practicality of this protocol.
European Journal of Organic Chemistry published new progress about Alkylation (dehydrative). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts