Davies, Sarah published the artcileTetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug, Product Details of C6H4N2, the main research area is tetrazine ketoprofen carboxylic acid antiinflammatory drug release; anti-inflammatory drugs; bioorthogonal decaging; inverse electron-demand Diels-Alder reaction; tetrazine; trans-cyclooctene.
In addition to its use for the study of biomols. in living systems, bioorthogonal chem. has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction to cleave trans-cyclooctene (TCO) and vinyl protecting groups from carboxylic acid-containing mols. The tetrazine-mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2 min). The anti-inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCO-prodrug in live macrophages. Overall, this work expands the scope of functional groups and the application of decaging reactions to a new class of drugs. ChemBioChem published new progress about Anti-inflammatory agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts