Chen, Xin published the artcileDesign, Synthesis and Biological Evaluation of 1-methyl-1H-pyrazole-5-Carboxamide Derivatives as Novel Anti-Prostate Cancer Agents, Quality Control of 1885-29-6, the main research area is human prostate cancer anticancer PSA antigen; Androgen receptor; antiproliferative activity; prostate cancer; prostate-specific antigen; pyrazole derivatives; structural modification..
The Androgen Receptor (AR) signaling functionis a critical driving force for the progression of Prostate Cancer (PCa) to bring about anti-prostate cancer agents, and AR has been proved to be an effective therapeutic target even for Castration-Resistant Prostate Cancer (CRPC). In order to discover novel anti-prostate cancer agents, we performed structural modifications based on the lead compounds T3 and 10e. A set of 1-methyl- 1H-pyrazole-5-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against both expressions of Prostate-Specific Antigen (PSA) and growth of PCa cell lines. Compound H24 was found to be able to completely block PSA expression at 10μM, and showed prominent antiproliferative activity in both the LNCaP cell line (GI50 = 7.73μM) and PC-3 cell line (GI50 = 7.07μM). These preliminary data supported a further evaluation of compound H24 as a potential agent to treat prostate cancer.
Anti-Cancer Agents in Medicinal Chemistry published new progress about Antiproliferative agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts