Qian, Deyun published the artcileLigand-Controlled Regiodivergent Hydroalkylation of Pyrrolines, Computed Properties of 100-70-9, the main research area is pyridine oxazoline ligand preparation; alkyalated pyrrolidine preparation regioselective; pyrroline halide hydroalkylation pyridine oxazoline ligand nickel catalyst; alkenes; heterocycles; hydroalkylation; nickel; reaction mechanisms.
Two series of C-alkylated pyrrolidines I [R = Boc, Cbz; R1 = i-Pr, cyclopentyl, indol-1-yl, etc.] and II [R2 = CO2Ph, Boc, Cbz; R3 = cyclohexyl, (CH2)3Ph, 2-thienyl, etc.] were synthesized via ligand controlled nickel-catalyzed regiodivergent hydroalkylation of 3-pyrrolines with alkyl/aryl halides. This method demonstrated broad scope and high functional-group tolerance and could be applied in late-stage functionalizations.
Angewandte Chemie, International Edition published new progress about Alkylation catalysts. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts