Vik, Erik C. published the artcileTransition-State Stabilization by n→π* Interactions Measured Using Molecular Rotors, SDS of cas: 1885-29-6, the main research area is Transition State stabilization Rotors NMR rotational barrier.
A series of 16 mol. rotors ,e.g. I (R= SMe), were synthesized to investigate the ability of n→π* interactions to stabilize transition states (TSs) of bond rotation. Steric contributions to the rotational barrier were isolated using control rotors, which could not form n→π* interactions. Rotors with strong acceptor π* orbitals, such as ketones and aldehydes, had greatly increased rates of rotation. The TS stabilization of up to ∼10 kcal/mol was consistent with the formation of a strong n→π* stabilization between the imide carbonyl oxygens and the ortho R group in the planar TS. Computational studies effectively modeled the TS stabilization and geometry, and NBO anal. confirmed the role of n→π* interactions in stabilizing the TS.
Journal of the American Chemical Society published new progress about Activation enthalpy. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts