Leijendekker, Leonardus H. published the artcileDevelopment, Scope, and Applications of Titanium(III)-Catalyzed Cyclizations to Aminated N-Heterocycles, Synthetic Route of 1885-29-6, the main research area is aminoindole aminopyrrole preparation fluorescence; imine cyclization titanium catalyzed; homogeneous catalysis; nitrogen heterocycles; reduction; titanium; umpolung.
The exceptionally mild conditions of a titanium(III)-catalyzed cyclization reaction paired with a convenient acid/base extraction was enabled the straightforward synthesis, isolation, and direct N-functionalization of amino heterocycles such as 3-aminoindoles I [R = Ph, 2-thienyl, 1-naphthyl, etc.] and -pyrroles. The unprotected heterocycles were ideal building blocks for the installation of aminated indoles and pyrroles into target mols., but their sensitivity had previously impeded their synthesis by modern catalytic methods. This full paper presented the development and extended scope of the new cyclization methodol. The transformation of the products into fused bis-indoles was also demonstrated along with the discovery of an unusual palladium-catalyzed reductive biphenyl coupling reaction. The titanium(III)-catalyzed cyclization had also been applied to the synthesis of substituted 3-iminoindolines, which were of potential interest for applications in natural product synthesis and exhibit tunable blue-to-green fluorescence properties.
Chemistry – A European Journal published new progress about Absorption spectra. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts