115279-57-7, name is 2-(4-Aminophenyl)-2-methylpropanenitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C10H12N2
Example 24; l-[4-(Cyano-dimethyl-methyl)-phenyl]- 3-{4-[2-(3-Hydroxy-propylamino)- pyrimidin-4-yloxy] -phenyl} -urea188 mg (1.16 mmol) lJ’-Carbonyl-diimidazol (CDI) were given to a solution of 175 mg (1.09 mmol) 4-(cyano-dimethyl-methyl)-phenylamine (Hicks, T.A., J. Med. Chem. 22 (1979) 1460-1464) in 4.0 ml dichloro-methane and stirred for 12 h.A solution of 284 mg (1.09 mmol) 3-[4-(4-Amino-phenoxy)-pyrimidin-2- ylamino]-propan-l-ol in 6 ml dichloromethane was added within 30 min. and the mixture stirred for 12 h at r.t. The reaction mixture was evaporated and the residue was purified by chromatography on silica gel (ethyl acetate). The obtained material was left overnight with dichloromethane, the precipitate filtered, washed with ether and dried. Yield: 180 mg (37%) of the title compound. MS: 447.58 (ESI+).eta-NMR(400Hz, [DJDMSO): delta = 1.59(br, 2H, CH2-CH2-CH2), 1.67(s, 6H, CH3), 3.22(br, 2H, CH2-NH), 3.38(br, 2H, CH2-OH), 4.37(br, IH, OH), 6.05(br, IH, 5- H-pyrimidine), 7.05(br, IH, CH2NH), 7.09(d, 2H, 3-H/5-H-Ar-NH), 7.41 (d, 2H,Ar-C-CN), 7.49(m, 4H, 2-H/6-H-Ar-NH, Ar-C-CN), 8.12(d, IH, 6-H-pyrimidine), 8.75(s, IH, urea-NH), 8.79(s, IH, urea-NH).
The synthetic route of 115279-57-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/77548; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts