Hennen, William J.’s team published research in Journal of Organic Chemistry in 50 | CAS: 5098-14-6

Journal of Organic Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Application In Synthesis of 5098-14-6.

Hennen, William J. published the artcileSynthesis of 4-substituted 5-amino-2-(β-D-ribofuranosyl)thiazoles and 4-substituted 5-amino-2-(β-D-ribofuranosyl)selenazoles, and their respective conversion into 2-(β-D-ribofuranosyl)thiazolo[5,4-d]pyrimidines and 2-(β-D-ribofuranosyl)selenazolo[5,4-d]pyrimidines. A new synthesis of tiazofurin and selenazofurin, Application In Synthesis of 5098-14-6, the publication is Journal of Organic Chemistry (1985), 50(10), 1741-6, database is CAplus.

Anhydroallonothioate (I; Z = S) and -selenoate (I; Z = Se), prepared by treatment of anhydroallonimidate (I; Z = NH) with H2S and H2Se, underwent cyclocondensation with H2NCH(CN)2, NCCN(NH2)CONH2, or NCCH(NH2)CO2Et to give C-nucleosides II (X = S, R = NH2, R1 = cyano; X = S, Se, R = NH2, R1 = CONH2; X = S, Se, R = NH2, R1 = CO2Et). II (X = S, R = NH2, R1 = cyano; X = S, Se, R = NH2, R1 = CONH2) were further cyclized with H2NCH:NH or HC(OEt)3 to give thiazolo- and selenazolopyrimidine C-nucleosides, e.g., III (X = S, Se). II (X = S, Se, R = NH2, R1 = CO2Et) were converted in 2 steps into tiazofurin and selenazofurin (II; X = S, Se, R = H, R1 = CONH2), resp.

Journal of Organic Chemistry published new progress about 5098-14-6. 5098-14-6 belongs to nitriles-buliding-blocks, auxiliary class Nitrile,Salt,Sulfonic acid,Amine,Benzene, name is 2-Aminomalononitrile 4-methylbenzenesulfonate, and the molecular formula is C10H11N3O3S, Application In Synthesis of 5098-14-6.

Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts