Fang, Zengjun published the artcileSynthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors, Computed Properties of 612-13-5, the publication is Chemical Biology & Drug Design (2015), 86(4), 614-618, database is CAplus and MEDLINE.
A series of (arylmethyl)(arylmethyltriazolylmethylthio)dihydropyrimidinones I (R = 1-naphthalenyl, 2,6-dichlorophenyl; R1 = H, I, Me; R2 = Ph, 4-FC6H4, 4-MeOC6H4, 4-H2NCOC6H4, 2-NCC6H4, 2-MeC6H4, 4-H2NSO2C6H4) were synthesized using copper-catalyzed azide-alkyne cycloadditions and evaluated as inhibitors of HIV-1. Among them, the most active HIV-1 inhibitor was compound I (R = 2,6-dichlorophenyl; R1 = Me; R2 = 4-H2NSO2C6H4), which exhibited similar HIV-1 inhibitory potency (EC50 = 3.22 U+03BCM) compared with 3TC (EC50 = 2.24 U+03BCM). None of these compounds demonstrated inhibition against HIV-2 replication. The preliminary structure-activity relationship (SAR) of these new derivatives was discussed briefly.
Chemical Biology & Drug Design published new progress about 612-13-5. 612-13-5 belongs to nitriles-buliding-blocks, auxiliary class Organic Pigment, name is 2-(Chloromethyl)benzonitrile, and the molecular formula is C8H6ClN, Computed Properties of 612-13-5.
Referemce:
https://en.wikipedia.org/wiki/Nitrile,
Nitriles – Chemistry LibreTexts