These common heterocyclic compound, 64248-62-0, name is 3,4-Difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 3,4-Difluorobenzonitrile
Step 1 (MM-Si):Potassium carbonate (22 g, 79.13 mmol) was added to a solution of 3-hydroxypyrrolidone hydrocloride (9.6 g, 79.12 mmol) in diemethylformamide (60 mL) and the mixture was stirredfor 15 mi 3,4-difluorobenzonitrile (10 g, 71 .94 mmol) was added and the mixture was stirred at 90C for 9 h. The reaction was cooled to room temperature and than quenched with ice water. The resulting mas was filtered and washed with water, pet ether and dried in vacuum to affordlO g (67.5%) of MM-Si as an off white solid.
The synthetic route of 3,4-Difluorobenzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PROBIODRUG AG; HEISER, Ulrich; BUCHHOLZ, Mirko; SOMMER, Robert; DEMUTH, Hans-Ulrich; WO2014/140279; (2014); A1;,
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