Electric Literature of 6621-59-6, A common heterocyclic compound, 6621-59-6, name is 6-Bromohexanenitrile, molecular formula is C6H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
6-Bromocapronitrile (1.19ml, 9.00mmol) and 3-buten-1-ol (946ul, H .Ommol) were added to a stirred solution of potassium hydroxide (6.16g, 110mmol) and tetra-butylammonium bromide (434mg, 1.35mmol) in water (6ml) and dichloromethane (2ml). The reaction was stirred at room temperature for 4 days and then washed with diethyl ether (2x50ml). The combined organics were washed with water (3x30ml), dried (magnesium sulphate) and the solvent removed in vacuo to furnish the title compound as a colourless oil, 1.48g. LRMS: m/z 168 [M+H]+.
The synthetic route of 6621-59-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER LIMITED; WO2007/107828; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts