Synthesis of 2-Aryl/Heteroaryloxazolines from Nitriles under Metal- and Catalyst-Free Conditions and Evaluation of Their Antioxidant Activities was written by Garg, Parul;Chaudhary, Shweta;Milton, Marilyn D.. And the article was included in Journal of Organic Chemistry in 2014.Synthetic Route of C12H14N2O This article mentions the following:
The synthesis of structurally diverse 2-aryl/heteroaryloxazolines from nitriles and amino alcs. has been achieved under metal- and catalyst-free conditions in good to excellent yields. An array of functional groups are well-tolerated, thus, allowing the introduction of many important biol. active motifs such as azoles, ring-fused azoles, saturated heterocyclics, and amines in 2-aryloxazoline scaffolds. E.g., condensation of 3-BrC6H4CN with H2NCH2CH2OH gave 83% 2-aryloxazoline derivative (I). An evaluation of the antioxidant properties using the DPPH (di-Ph picryl hydrazyl) assay method shows the pyrrole-functionalized 2-aryloxazoline to be the best antioxidant among all the synthesized 2-aryl/heteroaryloxazolines. In the experiment, the researchers used many compounds, for example, 4-(Morpholinomethyl)benzonitrile (cas: 37812-51-4Synthetic Route of C12H14N2O).
4-(Morpholinomethyl)benzonitrile (cas: 37812-51-4) belongs to nitriles. Nitrile carbon shifts are in the range of 115â?25 ppm whereas in isonitriles the shifts are around 155â?65 ppm. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Synthetic Route of C12H14N2O
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts