Solvent-free synthesis of 2-aminothiophene-3-carbonitrile derivatives using high-speed vibration milling was written by Xu, Fang;Li, Yujin;Xu, Fengshuang;Ye, Qing;Han, Liang;Gao, Jianrong;Yu, Wubin. And the article was included in Journal of Chemical Research in 2014.Quality Control of 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile This article mentions the following:
Solvent-free synthesis of 2-aminothiophene-3-carbonitrile derivatives e.g., I via one-pot cyclo-condensation of various ketones, malononitrile with elemental sulfur employing high-speed vibration milling with diethylamine as the catalyst was developed. The main advantages of this method are short reaction times, facile conditions, good yields, use of inexpensive catalyst and environmental friendly conditions. In the experiment, the researchers used many compounds, for example, 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2Quality Control of 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile).
2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile (cas: 70291-62-2) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Quality Control of 2-Amino-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carbonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts