Cobalt(II)/TPPMS-Catalyzed Dehydrative Nucleophilic Substitution of Alcohols in Water was written by Hikawa, Hidemasa;Ijichi, Yukiko;Kikkawa, Shoko;Azumaya, Isao. And the article was included in European Journal of Organic Chemistry in 2017.Computed Properties of C8H5F3N2 This article mentions the following:
A green and sustainable direct dehydrative amination of alcs., catalyzed by cobalt(II)/TPPMS (sodium diphenylphosphinobenzene-3-sulfonate) in water, is described. Earth-abundant cobalt was used as Co(hfac)2·xH2O (hfac: hexafluoroacetylacetone), which acts as a highly efficient Lewis acidic catalyst. This simple atom-economical protocol features mild conditions without the need for a base or other additives and affords the corresponding benzylic and allylic anilines along with water as the only coproduct. Mechanistic studies suggest that this system is driven by direct nucleophilic substitution of alcs. In the experiment, the researchers used many compounds, for example, 2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1Computed Properties of C8H5F3N2).
2-Amino-4-(trifluoromethyl)benzonitrile (cas: 1483-54-1) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Computed Properties of C8H5F3N2
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts